Co-founded by serial entrepreneur Paulo Costa and Dr. Robert Lustig, A neuroendocrinologist and author of popular science books such as’Fat Chance: Beat the odds against sugar, processed foods, obesity and disease, ‘Based in San Francisco BiolumanDesign an ingredient that combines natural polysaccharides that trap sugars and fats in the stomach.
Sugar and fats These ‘micro-jelly balls’ navigate insufficiently in the small intestine – where fats and sugars are usually digested by the body – and reach the colon.
Some of these folded sugars and fats are then ““Released within the colon, feed the microbiome and increase the bacterial production of short-chain fatty acids (prebiotic function), while the rest of the trapped ancestors that are not absorbed are secreted naturally (caloric elimination function).”Costa claims, who said the company received six patents.
He added: “We arrived early [to this technology], And so we managed to be wider than usual [IP] Coverage … As far as I know, this calorie elimination technology has never been used commercially. We hope to deploy it in the market as soon as possible. “
Several possible formats of shipping
He will not disclose the materials used in the latest wording (one published patent refers to “One or more hydrogels, soluble or insoluble fibers, waxes and / or gums … “), But says it can be supplied as a tablet or as a powdered supplement for consumption with a meal, or added to selected food products from chocolate spreads to jam and cookies. He added that the formulation is based on GRAS natural polysaccharides (commonly known as safe).
“BioLumen can be combined with small and tasty snacks that are eaten during the meal, which will leave the other foods in the stomach with their absorption and fat properties. or [you could include it] In a lower dose, like 3%, in pre-packaged foods like Nutella, chocolates, jams, sauces, cookies and breads. That 3% of BioLumen inside will be enough to wrap them in insoluble fiber once in the stomach; The gut will ‘see’ much more fiber and much less sugars and fats. “
“The difference is that we understand … it’s not just fiber strings”
So what’s special about fiber in BioLumen?
“BioLumen is a combination of natural polysaccharides, ” Said Costa, who has so far raised money from friends and family, accelerates Indibio’s biotechnology and is a private investor.
“The difference is that we understand. That’s the key. It’s not just fiber strings. Professor Lustig, the co – founder, keeps asking the following question: Is apple sauce closer to apple juice or apple?
“The correct answer is that it is much closer to apple juice. In apple sauce, the apple fruit structure is destroyed and your digestive tract is going to absorb everything quickly. Just adding the fiber is not going to make it. Our difference is that we reconnect the apple sauce to the fiber structure.”
What happens when you consume bioloman with sugary, fatty foods?
So what happens when we ingest BioLumen with sugary or fatty foods?
“In the stomach, micro-bits of BioLumen are released and then expand and absorb the sugar-rich fluids in the stomach,” Costa claims. “Then they gel them in and keep most of them during their next navigation in the digestive tract. Instead of being rapidly absorbed in the duodenum, the top of the gut, they continue to leak only some of their contents along the way.”
He adds: “Once they are in the colon, they are going to leak a lot more of their sugars and these sugars are now going to feed there the usually starved good bacteria, which are responsible for the fermentation of the short chain fatty acids. [such as butyrate].
“Most of these ‘good’ bacteria are starving because the duodenum eats them first as soon as they are out of the stomach. Instead, BioLumen now feeds them“, Claims Costa.
“It should be remembered that our digestive system and its microbiome evolved over millions of years in hunter-gatherer foods that were rich and complex in hard-to-breakdown fiber and lacked easy-to-absorb sugars. Therefore the percentage of absorption of food ingested in different parts of the digestive system in our ancient past was completely different. We have the old gut [of our Paleolithic ancestors] but [today consume] totally diffrent Food [diet]. ”
Encouraging order test results … but there are still no human trials
So what evidence does Costa have that supports the above hypothesis? How easy is it to mimic conditions in the stomach, small intestine and then the colon as part of an order, and has he conducted clinical trials in humans showing caloric reduction or digestive benefits?
“ We have not yet performed clinical trials in humans showing caloric elimination“He says. “But the customer [laboratory studies] Pretty promising. Human tests are as follows.
“We have hired a European Contract Research Organization (CRO) that simulates the digestive system for pharma and nutritional companies, using the most respected SHIME. [Simulator of the Human Intestinal Microbial Ecosystem] model. [SHIME is an invitro simulator model of the human digestion system]. They checked the biomoman from top to bottom [the digestive system]. ”
Invitro tests have shown a significant increase in short-acting fatty acid production butyrate, Costa says.
So how much fat and sugar does BioLumen consume?
“Of course BioLumen is unable to absorb allThe sugars, “Says Costa.”We are talking here in percentages. BioLumen will only reduce the percentage of sugars absorbed. “
Is there a downside?
As for preventing the absorption of certain fats, can there be any disadvantages? Famous, for example, Ulstra had messy side effects (anal leakage) and inhibited the absorption of fat-soluble vitamins.
“BioLumen does not eliminate fat, “Costa emphasizes.”This will simply reduce the amount to be absorbed. But any low-calorie diet will do just that. “
Satiety and fullness
As for the physical sensation it imparts ‘Extremely expandable fibers’ Does BioLumen affect satiety in any way and if so, what is the mechanism?
“Definitely“, Claims Costa.”By consuming bioluminescent, at any given moment you have a much larger mass along the digestive tract … a lot of receptors and compounds along the way continue to signal it to the brain. “
PepsiCo’s Greenhouse Program
So what’s next, and what BioLumen hopes to get out of working with PepsiCo in the CPG industry Greenhouse program?
“We see PepsiCo’s greenhouse program as a great opportunity“He says. “PepsiCo’s latest selection of dishes is very heavy in recent nutritional scientific discoveries, and makes it very clear that PepsiCo is quite committed to examining consumer trends in health and nutrition.
“And BioLoman’s mission is exactly that. PepsiCo, as one of the leading food and beverage companies, has tremendous expertise in food, marketing and distribution sciences, and feels we can learn a lot from the mentors we work with.”
- Read more hereOn PepsiCo’s incubator program and the other finalists in the fifth group, each of whom will receive $ 20,000 grant funding and begin a six-month business plan designed to accelerate their growth through personal mentoring.